There are several museums in Zacatecas, including the Museo Francisco Gottia with it's sculptures and paintings, the Museo Pedro Coronel featuring unique private works and the Museo Rafael Coronel with it's extensive exhibit of masks and figurines.

The Coronel brothers, Pedro and Rafael, seem to have been the city's favorite sons, and each has an impressive museum named for him. Pedro was a famous painter, and also collected works by famous European artists, such as Picasso, Dali, and Miro. The Pedro Coronel Museum features these collected pieces along with many works by the artist himself. Rafael was also an art collector, but one who seemed to have had quite a thing for masks since there are literally thousands of them on display in the Rafael Coronel Museum, most from indigenous Mexican cultures, along with sculptures, hundreds of puppets, and other objects.

The city of Zacatecas was  declared a World Heritage site, with stunning religious and civil buildings built by the church. Its culture thrives on Mexican cowboys, silver pieces and leatherwork and is home to some of the most important museums in the country, including a museum featuring masks from every region, and a museum that exhibits sculptures and paintings from the Greek and Picasso eras.

The most famous cathedral is Zacatecas is  the Zacatecas Cathedral.  It is stunningly ornate with three levels of columns with inset sculptures and a huge, round, stained glass window over the carved wood doors.
Another cathedral is the Basilica Cathedral. It was rebuilt according to the architectural and decoration pattern of the 17th and 18th century design attributed to C. Fansago, architect and sculptor, who certainly worked at the reasset of the Presbytery in 1627-1628 and who designed the High Altar in 1645. Much of the pre-existing marble has been reutilized for repaving the Cathedral and to inlay its walls.

However, all frescoes and pictorial decorations of the vaults and the canvas paintings on the walls of the Basilica have gone lost. A huge painting by L. Giordano representing the consacration of the Basilica in 1071 (a sketch of whitch can be viewed in the Museum) formerly embellished the internal facing wall. It is now replaced by a 40 square meters fresco by P. Annigoni (1979): The Glory of St. Benedict or The Benedictine Paradise, featuring St. Benedict surrounded by monks, bishops, nuns who lived in holiness by following his Rule. These include three Popes on the foreground: at the left St. Gregory the Great, who was St. Benedict's first biographer;
in the middle Pope Paul VI who reconsacrated the Basilica in 1964 and proclaimed St. Benedict the main Patron Saint of Europe; on the right St. Victor III, formerly Abbot Desiderius, author of Montecassino's splendour in the 12th century. Two personages of the Old Testament, Abraham on the left and Moses on the right, are portrayed in the two fan-windows at both sides of the marigold window. St. Benedict, as Father of many Populations and as Legislator for the whole Monastic Order in the West has particular affinities with these two, Patriarchs.