What are surgical infections? These are the infections related with surgical procedures or the ones possible to be treated surgically. According to the clinical aspects, there's a wide spectrum of surgical infections known nowadays. The best surgical infections examples include surgical site infections, soft tissue infections, cavity infections, abscesses and some other specific infections (liver abscess, appendicitis, acute cholecystitis, etc.). Surgical site infections are considered to be the second most frequent hospital infections. They tend to lead to prolonged hospital stay, increased morbidity and mortality, and as a result - increased cost. According to modern medical studies, there are several factors involved in the development of such infections. They are known to be classified at microbe pathogen, host and environment related. Thus, the clinical outcome of any surgical infection depends on the immunity of the host and the effect of the attacking organism. Therefore it's important to pay attention to the surgical infections therapy, treatment and prevention. Strict consideration of tissues surgical handling is a must. This will help to minimize possible iatrogenic contribution to the increased surgical infection rates. Surgical infections therapy means taking into account basic prevention rules. They include proper septic and antiseptic procedures, proper surgical techniques and chemoprophylaxis use. The mentioned principles are considered to be alternative to each other but at the same time - adjuvant. Thus, a key to surgical infections therapy and management is prevention. As a matter of fact, one of the most commonly used surgical infections therapy is a two-stage prosthetic exchange, which is known to be separated by six weeks of intravenous surgical infections drug therapy (or with antibiotics). The mentioned procedure usually results in long-term hospitalization, severe functional impairment, morbidity and in some severe cases - increased mortality. For this reason, modern medical experts have developed new and challenging approaches to surgical infections therapy. Depending on the type of microorganism, clinical presentation and antibacterial susceptibility the following approaches to surgical infections treatment can be used: less aggressive surgical techniques, various combinations of antibiotics. It's necessary to keep in mind that antibiotics should target the pathogens generally associated with the undertaken operation. However, they can not replace aseptic and meticulous surgical technique. There may be some difficulties with the determination of antibiotic surgical infections therapy efficiency. The reason for this may be the absence of exact information regarding the type of the surgical procedure which had been performed. Nevertheless, antibiotic treatment of surgical infections is still considered to be one of the most beneficial.