Most frequently the reason of male infertility becomes infringement functioning of endocrine system. Endocrine system consists of several glands of external and internal secretion. The substances allocated by glands, refer to as hormones. Hormones provide growth, development of an organism, sexual differentiation of the human and normal functioning of reproductive system.

Hypothalamic disease concerns to a category of diseases of endocrine system. Hypothallus is the gland of internal secretion. Same it is located in the brain. Functioning of hypothallus is closely connected to functioning of hypophysis. Correctly coordinated work of both glands provides normal functioning of sexual system, growth and development of an organism. Most frequently the reasons of hypothalamic disease are cranio-cereberal trauma, an infection, strong stress, tumoral process, an intellectual overstrain.

Hypothalamic disease can arise at sharp weight reduction or owing to carrying out of hormonal therapy. The additional factor, provoking the occurrence of hypothalamic disease is the alcoholic intoxication of an organism. In most cases at the constant use of the big dozes of alcohol, hypothalamic disease develops promptly and practically does not give in to treatment. Rather frequently hypothalamic disease is accompanied by the occurrence of accompanying diseases.

At hypothalamic disease functioning of hypophysis and produce of gonadotrophic hormones is broken; there is a dysfunction of nervous and reproductive systems, the consequence of which male infertility becomes.

Treatment for hypothalamic disease is considered to be a very long process. During the treatment the complex method is used. According to the standard techniques, for treatment for hypothalamic disease hormonal preparations, physiotherapy, reflexotherapy and moderate physical activity are applied. There are some forms of hypothalamic disease. In some of them hypothalamic disease is complicated of additional diseases. One of such diseases is Kallmann's syndrome.

Kallmann's syndrome is one of the rarest diseases of male reproductive system, which complicates with infertility. Kallmann's syndrome is characterized by presence of isolated deficiency of gonadotropinum. The given disease arises at 1 man from 10000. At Kallmann's syndrome, besides infertility, accompanying syndromes as anosmatic syndrome (infringement of sense of smell), congenital deafness, harelip, crevice of the firm palate, craniofacial asymmetry, infringement function of kidneys, color blindness are frequently observed.

At this disease functioning of hypophysis is not broken. Besides Kallmann's syndrome is characterized by a delay of sexual development and the size of testicles does not exceed 2 cm in diameter.

At such disease normal functioning of male genitals is practically impossible. Produce of viable spermatozoon and occurrence of long and high-grade erection happens extremely seldom.