Bio-implants are materials of animal and human origin which are offered after preparation or conservation to tissue replacement. They are widely used in ENT (Ear, Nose and Throat). Any implants review tells that one of the most important requirements to the implant is the infection security. The success of any surgical procedure greatly depends on the surgical technique which includes hemostasis, sterility and proper tissue handling. When the surgery involves the use of bio-implants, the role of sterility gets even bigger. It is quite possible that some violations of the sterile technique can pass unnoticed in a simple surgery of soft tissue. As for the surgeries with bio-implants, such violations can become very serious. While performing a simple surgery, it is possible to prevent bacterial contamination in different ways. The surgeon uses sterile saline to rub the area to be operated. This removes tissue contaminants and debris from the area. After the surgery the body fights and removes the bacteria. Antibiotics that are taken after the operation are also able to kill bacteria. Normal circulation diffuses the antibiotic and allows it to work in contaminated areas. Sterility is of paramount importance at the surgeries involving some foreign material transplantation. It is worthy of note that the body's forces do not work so effectively in the presence of bio-implants. When a foreign body is present, antibiotics do not work properly either. The presence of a foreign object gives a surface to bacteria where they can colonize. The surface does not have the blood supply to deliver either blood cells or antibiotics to the area. It means that the body has to depend on the white blood cells motility and antibiotic diffusion to treat the area. Bio-implants can also provide bacteria with the place for them to hide and not to be reached by antibiotics and white blood cells. It is possible to conclude that most of the bacteria can be removed from the site as long as antibiotics are used. When the patient discontinues taking antibiotics the population of bacteria which is left can re-establish the infection. It is also possible that tissue inflammation can occur because of the presence of bio-implants. Together with the post-surgical inflammation, it can cause the formation of an increased amount of the fibrotic tissue during the process of healing. The fibrotic tissue is usually poorly vascularized if compared to the normal subcutaneous or muscle tissue. The poor circulation prevents adequate establishing of antibiotic concentrations at the surgery site and reduces the amount of available white blood cells. The most aggressive treatment can be useless if a bacterial infection gets transmitted to the implant site. It is necessary to remove implanted materials before resolving the infection. The development of packaging processes is a method of easier maintenance of sterility. The new packages should let the surgeon open transmitter packages with a lower risk of contamination.