To the termination of the supervision term almost 68 % of the patients receiving an antidepressant medicine were alive in comparison with 35.7 % of patients, treated by means of placebo (ð=0.004) were alive almost. The wide selection of means for antidepressant therapy equally influenced survival rate.
The most interesting fact concerning antidepressant therapy was that the antidepressant side effects were not significant in comparison with positive influence. That fact did not depend on presence of depression. It has been shown earlier, that after the stroke depression hits 40 % people, initially depression not suffering. Based on their data the American scientists believe that they should prescribe antidepressant therapy to all patients after the stroke for improvement of survival rate.
According to statistics, the mental frustration make 8,1 % of the general number of diseases, and the depression is the most wide-spread among all mental diseases. Depressive frustration is a very frequent one, and the antidepressant therapy, as a result, is the most common phenomenon in the common-medical practice. On average, the depressive frustration makes more than 10 % occasions when patients go to doctors of other specializations, not psychiatrists.
If we study the sex of patients, who used the antidepressant therapy, then we can see that depressions affect women more frequently than men. As sexual distinctions affect frequency of disease and the depressive spectrum seize the beginning of the pubertal period and proceed on the average until 55 years, it is possible to count, that not only genetic and psychosocial, but also biological and neuroendocrinal factors play a considerable role in development of depressions in women and men.
There are many ways of classification of depressive frustration. Mutual relations between etiology, symptoms, the biochemical processes underlying disease, reaction to treatment and outcomes of affective frustration are insufficiently investigated till now and do not allow to classify them unequivocally. The classification of antidepressant medicine at present time responds the practical purposes first of all.
According to this classification, there are three degrees of antidepressant therapy, which are used for certain purposes and are chosen of the basic symptoms and severity of injury. Depressive frustration can practically accompany with any disease. However, now it is determined that peaks of depressive frustration are observed during the hormonal reorganization, accompanying by change in a level of sexual hormones in lutein phase of period (the premenstrual syndrome); after sorts (postnatal depression) and during the period menopause.
The antidepressant therapy is used to ease stress and the hormonal changes influencing the fluctuation of mood. It became the universal disaster of the twenty-first century! The recent researches in the field of antidepressant therapy show that change of a hormonal level is more important factor than simply low concentration of hormones.