Le Blanc graduated from the Newton North High School in 1985. After high school he attended college at Wentworth Institute of Technology, in Boston, M.A. However he left some days after the beginning of his second semester. The father of Le Blanc is Paul Le Blanc, and his mother is Pat Grossman,and he is of a mixed Irish, Dutch, English and Acadian descent on his father's side, and of the Italian ancestry from his mother's. It is to be noted that Le Blanc is almost always cast as Italian. From his childhood he had interest on many aspects. When he was around eight years old he had an intense desire to be a motorcycle racer. For which he entered into junior competitions until finally giving it up. On the other hand Le Blanc got trained and did well in carpentry when he was young, winning the "Golden Hammer" award while attending high school. Around this time he was also cast as Jesus in Jesus Christ Superstar at the Cultural Arts Playhouse. Besides Le Blanc also portrayed Sonny in Grease, there winning the illustrious "CAP" award for his performance. It was in the late 1980s when Le Blanc started appearing in a number of television ads, that included the famous spots for Heinz, Levi's, and last but not the least, Coca Cola. In the year 1988, he landed his first regular TV role, on the drama TV101 which in a successful note ran for one season. In 1991 he was perceived in the music video for Alanis Morissete's single "Walk Away", where he played her boyfriend. In the same year of 1991, he went on to star in a spin off of Married With Children entitled Top of the Heap. The short lived series only lasted 7 episodes in April and May of 1991. He would also play his Top of the Heap character Vinnie Verducci in a number of Married With Children episodes.
Le Blanc finally reached the zenith of success when he landed in the role of Joey Tribbiani in the year 1994 and would go on to play him for twelve years, over ten seasons of Friends and two seasons of Joey. When LeBlanc gave his audition for the role as Joey Tribbiani he only had $11 However, when the cast got their paychecks, the first thing he bought was a hot dinner. Friends was without a single doubt hugely successful and Le Blanc, in conjunction with his co-stars, gained wide recognition among television viewers. The cast received a salary of one million dollars per episode for the last two seasons of Friends. Le Blanc's most notable movie roles have been in the films Ed in 1996, Lost in Space in 1998, Charlie's Angels in 2000 and All the Queen's Men in 2001.
As a prestigious and highly successful film personality Le Blanc at several times has been bestowed with great many awards. For the years 2002-2004, Le Blanc was nominated for the three consecutive years as the Best Actor at the Emmy Awards, while from 2003-2005 he received three consecutive Best Actor nominations at the Golden Globe Awards. In the year 2000, he became succesful to win the Editor's Choice in TV Guide Awards as Friends. In the year 2002, he won TV - Choice Actor - Comedy at the Teen Choice Awards for the same film Friends. In 2005, he won Favorite Male Television Star at the People's Choice Awards.